“Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models.”

Abstract excerpt

Functional analysis in mouse models is necessary to establish the involvement of a set of genetic variations in tumor development. Many lung cancer models have been developed using genetic techniques to create gain- or loss-of-function alleles in genes involved in tumorigenesis; however, because of their labor- and time-intensive nature, these models are not suitable for quick and flexible hypothesis testing. Here...

Topics

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• Adenocarcinoma
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Gene Editing
• Genes, Tumor Suppressor
• Lentivirus
• Lung Cancer Research Studies

Identifiers and source

Literature Corpus work

8a5b411c-552e-5be2-a75a-44e3c164f715

DOI

10.1101/2023.12.21.572771