The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice.

Abstract excerpt

CRISPR/Cas9 systems have revolutionised the field of gene editing, allowing for precise modifications to be generated in vivo to mimic the genetic events found in human cancer cells. These systems may be used to generate germline or somatic loss-of-function of events, and also chromosomal rearrangements, either constitutively or in a spatiotemporally controlled manner. Forward genetic screens have also been...

Topics

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• CRISPR-Cas Systems
• Disease Models, Animal
• Gene Editing
• Mice
• Neoplasms