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A multiplexed in vivo approach to identify driver genes in small cell lung cancer

1 Jan 2023

Abstract excerpt

Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate regulators of tumor initiation and growth in genetically engineered mouse models of SCLC. We found that naphthalene pre-treatment enhances lentiviral vector-mediated SCLC...

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PMID: 36640300
DOI: 10.1016/j.celrep.2023.111990

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