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Article

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.

Nature communications - 23 Jun 2021

Teng Yu-Ching, Sundaresan Aishwarya, O'Hara Ryan, Gant Vincent U, Li Minhua, Martire Sara, Warshaw Jane N, Basu Amrita, Banaszynski Laura A

Abstract excerpt

ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes cells to chemical stabilizers of G4 structures, the molecular function of ATRX at G4 regions during replication remains unknown. Here, we demonstrate that ATRX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34162889
DOI: 10.1038/s41467-021-24206-5
PMCID: PMC8222256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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