Article
DNA Damage in Stem Cells.
Molecular cell - 4 May 2017
Vitale Ilio, Manic Gwenola, De Maria Ruggero, Kroemer Guido, Galluzzi Lorenzo
Abstract excerpt
Both embryonic and adult stem cells are endowed with a superior capacity to prevent the accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells, which would be particularly detrimental to the whole organism. Inducible pluripotent stem cells also display a robust DNA damage response, but the stability of their genome is often conditioned by the mutational history of the cell...
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