CancerSTFormer enables multi-scale analysis of spot-resolution spatial transcriptomes and dissects gene and immune regulatory responses to targeted therapies

Abstract excerpt

The growing number of spot-resolution sequencing based spatial transcriptomic (ST) datasets provides an unprecedented opportunity to study multicellular spatial niches driving cancer transitions. However studying niche-level behavior of tumors remains challenging as it requires a multi-scale approach to modeling the spatial niches and the ability to predict possible effects of genetic perturbations on spatial nich...

Topics

Open a Topic to create a Post that cites this publication.

• Biomarkers, Tumor
• Gene Expression Regulation, Neoplastic
• Neoplasms
• Phenotype
• Single-Cell Gene Expression Analysis
• Stomach Neoplasms
• Transcriptome
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

5f5f4875-831a-50f2-866a-45f61c676a50

DOI

10.64898/2025.12.22.696102