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Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma

15 Mar 2022

Abstract excerpt

The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients. Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution, hi-res spatial investigations are limited. In this study, we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38933545
DOI: 10.1016/j.fmre.2022.01.036

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