Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer

1 Apr 2024

Abstract excerpt

Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we analyze trajectory inference, deconvolute spatial transcriptomics at single-cell level and perform functional assays to generate a high-resolution integrated map of breast cancer (BC), with a focus on inflammatory and myofibroblastic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Immune cells in cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38561380
DOI: 10.1038/s41467-024-47068-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancerPMID 38561380Read ↗

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironmentSemantic proximity Read ↗

Spatially organized cancer-associated fibroblast subtypes partition cutaneous carcinomas into immune-active and contracted, immune-repressed nichesSemantic proximity Read ↗

Pan-Cancer Spatial Profiling Reveals Conserved Subtypes and Niches of Cancer-Associated FibroblastsSemantic proximity Read ↗

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic TargetsSemantic proximity Read ↗

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.Semantic proximity Read ↗

Mapping Breast Cancer Microenvironment Through Single-Cell OmicsSemantic proximity Read ↗

Multi-omics analysis identifies BICC1+ fibroblasts drive triple negative breast cancer aggressiveness and poor prognosisSemantic proximity Read ↗

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencingSemantic proximity Read ↗

Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancerSemantic proximity Read ↗

SpottedPy quantifies relationships between spatial transcriptomic hotspots and uncovers environmental cues of epithelial-mesenchymal plasticity in breast cancerSemantic proximity Read ↗

Analysis of intratumoral immune heterogeneity reveals spatial organisation of immunosuppression in breast cancerSemantic proximity Read ↗

Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.