Article

Detecting phenotype-specific tumor microenvironment by merging bulk and single cell expression data to spatial transcriptomics

2024-02-26

Abstract excerpt

In addressing the limitations of current multimodal analysis methods that largely ignore phenotypic data, leading to a lack of biological interpretability at the phenotypic level, we developed the Single-Cell and Tissue Phenotype prediction (SCTP), a deep-learning-based multimodal fusion framework. SCTP can simultaneously detect phenotype-specific cells and characterize the tumor microenvironment of pathological t...

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Literature Corpus work: 82b558e1-369b-553e-bd9f-ef2ac8a225a9
DOI: 10.1101/2024.02.23.581547

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