Article

CiFi: Accurate long-read chromosome conformation capture with low-input requirements

2025-02-05

Abstract excerpt

Hi-C characterizes three-dimensional chromatin organization, facilitates haplotype phasing, and enables genome-assembly scaffolding, but encounters difficulties across complex regions. By coupling chromosome conformation capture (3C) with PacBio HiFi long-read sequencing, here we develop a method (CiFi) that enables analysis of genomic interactions across repetitive regions. Starting with as little as 60,000 cells...

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Identifiers and source

Literature Corpus work: 89f41889-625a-50d4-b595-53628474a3db
DOI: 10.1101/2025.01.31.635566

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