Article

Accurate chromosome-scale haplotype-resolved assembly of human genomes

2019-10-18

Abstract excerpt

Haplotype-resolved or phased sequence assembly provides a complete picture of genomes and complex genetic variations. However, current phased assembly algorithms either fail to generate chromosome-scale phasing or require pedigree information, which limits their application. We present a method that leverages long accurate reads and long-range conformation data for single individuals to generate chromosome-scale p...

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Literature Corpus work: 427d71d6-9e47-5492-a4d2-f4729e3430ad
DOI: 10.1101/810341

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