Reference-Guided Chromosome-by-Chromosome de novo Assembly at Scale Using Low-Coverage High-Fidelity Long-Reads with HiFiCCL.

Abstract excerpt

Population genomics using short-read resequencing captures single-nucleotide polymorphisms and small insertions and deletions but struggles with structural variants, leading to a loss of heritability in genome-wide association studies. In recent years, long-read sequencing has improved pangenome construction for diverse eukaryotic species, including humans, crops, and other organisms of ecological and economic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosomes
• Share to Genomics