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Article

Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2015

Castillo Karen, Contreras Gustavo F, Pupo Amaury, Torres Yolima P, Neely Alan, González Carlos, Latorre Ramon

Abstract excerpt

Being activated by depolarizing voltages and increases in cytoplasmic Ca(2+), voltage- and calcium-activated potassium (BK) channels and their modulatory β-subunits are able to dampen or stop excitatory stimuli in a wide range of cellular types, including both neuronal and nonneuronal tissues. Minimal alterations in BK channel function may contribute to the pathophysiology of several diseases, including...

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Identifiers

PMID: 25825713
DOI: 10.1073/pnas.1504378112
PMCID: PMC4403153

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