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Regulation of large-conductance Ca <sup>2+</sup> - and voltage-gated K <sup>+</sup> channels by electrostatic interactions with auxiliary β subunits

2021-02-22

Abstract excerpt

Large-conductance Ca 2+ - and voltage-gated K + (BK K Ca 1.1) channel complexes include pore-forming Slo1 α subunits and often auxiliary β subunits, latter of which noticeably modify the channel’s pharmacological and gating characteristics. In the absence of intracellular Ca 2+ , β1 and β4 modestly shift the overall voltage dependence of the channel to the positive direction by decreasing the probability that...

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Literature Corpus work
0ae2ea1b-bd9a-5855-9303-7fb0f06301b5
DOI
10.1101/2021.02.22.432338
Open publication

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Regulation of large-conductance Ca <sup>2+</sup> - and voltage-gated K <sup>+</sup> channels by electrostatic interactions with auxiliary β subunitsDOI 10.1101/2021.02.22.432338
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