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Article

Structural basis of voltage-dependent gating in BK channels.

Nature communications - 1 Jul 2025

Contreras Gustavo F, Shen Rong, Latorre Ramon, Perozo Eduardo

Abstract excerpt

The allosteric communication between the pore domain, voltage sensors, and Ca2+ binding sites in the calcium- and voltage-activated K+ channel (BK) underlies its physiological role as the preeminent signal integrator in excitable systems. BK displays shallow voltage sensitivity with very fast gating charge kinetics, yet little is known about the molecular underpinnings of this distinctive behavior. Here, we...

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Identifiers

PMID: 40593533
DOI: 10.1038/s41467-025-60639-y
PMCID: PMC12218146

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