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Article

Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells.

Scientific reports - 23 Dec 2019

Laksitorini Marlyn D, Yathindranath Vinith, Xiong Wei, Hombach-Klonisch Sabine, Miller Donald W

Abstract excerpt

Wnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions. In the present study, a comprehensive characterization of the relevant genes, transport and permeability processes influenced by both the autocrine and external activation of Wnt signaling in human brain endothelial cells was examined using hCMEC/D3 culture...

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Identifiers

PMID: 31873116
DOI: 10.1038/s41598-019-56075-w
PMCID: PMC6928218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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