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Oligodendrocyte precursors migrate along vasculature in the developing nervous system

21 Jan 2016

Abstract excerpt

Oligodendrocytes myelinate axons in the central nervous system and develop from oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development. We show that OPCs require the vasculature as a physical substrate for migration. We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and...

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PMID: 26798014
DOI: 10.1126/science.aad3839

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