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Article

Human marginal zone B cell development from early T2 progenitors.

The Journal of experimental medicine - 5 Apr 2021

Tull Thomas J, Pitcher Michael J, Guesdon William, Siu Jacqueline H Y, Lebrero-Fernández Cristina, Zhao Yuan, Petrov Nedyalko, Heck Susanne, Ellis Richard, Dhami Pawan, Kadolsky Ulrich D, Kleeman Michelle, Kamra Yogesh, Fear David J, John Susan, Jassem Wayel, Groves Richard W, Sanderson Jeremy D, Robson Michael G, D'Cruz David P, Bemark Mats, Spencer Jo

Abstract excerpt

B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories. IgMhi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch and are...

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Identifiers

PMID: 33538776
DOI: 10.1084/jem.20202001
PMCID: PMC7868795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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