Article

Human marginal zone B cell development from early T2 progenitors

2020-09-25

Abstract excerpt

B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2 and T3 stages to become naïve B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgM hi and IgM lo developmental trajectories. IgM hi T2 cells have higher expression of α4β7 integrin and lower expression of IL4 receptor (IL4R) compared to the IgM lo branch and are selec...

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Literature Corpus work: 8297eb2f-72fe-5fde-9bd6-7710199ee87c
DOI: 10.1101/2020.09.24.311498

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