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Article

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy

7 Jun 2019

Abstract excerpt

Understanding the biological functions of tau variants can illuminate differential etiologies of Alzheimer's disease (AD) and primary tauopathies. Though the end-stage neuropathological attributes of AD and primary tauopathies are similar, the etiology and behavioral outcomes of these diseases follow unique and divergent trajectories. To study the divergent physiological properties of tau variants on a uniform...

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PMID: 31261380
DOI: 10.1093/hmg/ddz151

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