Article

Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau AD Inoculum

2021-10-27

Abstract excerpt

<title>Abstract</title> <p>Background: Several studies have demonstrated the capacity for seeding and spreading of tau-enriched fractions of brain homogenates from AD and other human and mouse tauopathies following intracerebral inoculation into transgenic mice bearing human tau or mutant human tau and into WT mice. However, little attention has been paid about the importance of host tau in tau seeding. <h4>Metho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4992c0c3-ae3a-5e5f-b953-e1ecdf305416
DOI: 10.21203/rs.3.rs-889543/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau AD InoculumDOI 10.21203/rs.3.rs-889543/v2Read

Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum.Semantic proximity Read

Relevance of host tau in tau seeding and spreading in tauopathiesSemantic proximity Read

Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsSemantic proximity Read

Transmission of tauopathy strains is independent of their isoform compositionSemantic proximity Read

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.Semantic proximity Read

Tau Seeding Mouse Models with Patient Brain-Derived AggregatesSemantic proximity Read

Comparative Analysis of Primary (3R/4R) versus Secondary (3R + 4R) Tauopathy Strains in Rodent Models: A Systematic ReviewSemantic proximity Read

Spreading of Tau Protein Does Not Depend on Aggregation PropensitySemantic proximity Read

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathySemantic proximity Read

Common mouse models of tauopathy reflect early but not late human diseaseSemantic proximity Read

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's DiseaseSemantic proximity Read