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Article

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.

Acta neuropathologica - 1 Apr 2016

Vasconcelos Bruno, Stancu Ilie-Cosmin, Buist Arjan, Bird Matthew, Wang Peng, Vanoosthuyse Alexandre, Van Kolen Kristof, Verheyen An, Kienlen-Campard Pascal, Octave Jean-Noël, Baatsen Peter, Moechars Diederik, Dewachter Ilse

Abstract excerpt

Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ) induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in conversion from preclinical cognitively normal to Alzheimer's Disease (AD), while the underlying mechanism remains unclear. In vivo preclinical models have reproducibly recapitulated Aβ-induced Tau-pathology. Tau pathology was thereby...

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Identifiers

PMID: 26739002
DOI: 10.1007/s00401-015-1525-x
PMCID: PMC4789256

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