Article

A dual role in virion attachment and entry makes the human cytomegalovirus gHgLgO trimer the central player in virion infectivity

2024-11-30

Abstract excerpt

Glycoproteins in the viral envelope of human cytomegalovirus (HCMV) orchestrate virion tethering, receptor recognition and fusion with cellular membranes. The glycoprotein gB acts as fusion protein. The gHgL complexes gHgLgO and gHgLpUL(128,130,131A) define the HCMV cell tropism. Studies with HCMV lacking gO had indicated that gO, independently of binding to its cellular receptor PDGFRα, plays an important second...

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Literature Corpus work: 711aa74b-d5f7-5c4c-90bd-329f440f70e0
DOI: 10.1101/2024.11.29.625639

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