Article

Heparanase, a host gene that potently restricts retrovirus transcription

2024-12-06

Abstract excerpt

Heparanase (HPSE) is a heterodimeric β-D-glucoronidase that is critical in mammalian cells for the enzymatic cleavage of membrane associated heparan sulfate moieties. Apart from its enzymatic function, HPSE has important non-enzymatic functions, which include transcriptional regulation, chromatin modification and modulation of various signaling pathways. Interestingly, while HPSE is an interferon stimulated gene,...

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Literature Corpus work: 79acc962-4124-5a7e-8503-eb4c805a176c
DOI: 10.1101/2024.12.06.627204

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