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Article

Heparan sulfate mediates infection of high-neurovirulence Theiler's viruses.

Journal of virology - 1 Aug 2002

Reddi Honey V, Lipton Howard L

Abstract excerpt

The mechanisms by which Theiler's murine encephalomyelitis virus (TMEV) binds and enters host cells and the molecules involved are not completely understood. In this study, we demonstrate that the high-neurovirulence TMEV GDVII virus uses the glycosaminoglycan heparan sulfate (HS) as an attachment factor that is required for efficient infection. Studies based on soluble HS-mediated inhibition of attachment and...

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Identifiers

PMID: 12134043
DOI: 10.1128/jvi.76.16.8400-8407.2002
PMCID: PMC155119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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