Article

Structure of the human heparan sulfate polymerase complex EXT1-EXT2

2022-06-19

Abstract excerpt

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by the bi-functional glycosyltransferases EXT1 and EXT2, which generate the glycan backbone consisting of repeating N -acetylglucosamine and glucuronic acid units. The molecular mechanism of heparan sulfate chain polymerization...

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Literature Corpus work: 0caf43c0-9d8f-5cb7-91ba-196a22483714
DOI: 10.1101/2022.06.19.496623

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