Article
The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.
Cell - 4 May 2017
Rialdi Alexander, Hultquist Judd, Jimenez-Morales David, Peralta Zuleyma, Campisi Laura, Fenouil Romain, Moshkina Natasha, Wang Zhen Zhen, Laffleur Brice, Kaake Robyn M, McGregor Michael J, Haas Kelsey, Pefanis Evangelos, Albrecht Randy A, Pache Lars, Chanda Sumit, Jen Joanna, Ochando Jordi, Byun Minji, Basu Uttiya, García-Sastre Adolfo, Krogan Nevan, van Bakel Harm, Marazzi Ivan
Abstract excerpt
The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis. Congenital mutations in RNA exosome genes are associated with neurodegenerative diseases. Little is known about the role of the RNA exosome in the cellular response to pathogens. Here, using NGS and human and mouse genetics, we show that influenza A virus (IAV) ribogenesis and growth are suppressed by impaired RNA exosome...
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