Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes.

doi:10.3324/haematol.2021.280016

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Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes.

Haematologica - 1 Oct 2022

Anastasopoulou Stavroula, Nielsen Rikke Linnemann, Als-Nielsen Bodil, Banerjee Joanna, Eriksson Mats A, Helenius Marianne, Heyman Mats M, Johannsdottir Inga Maria, Jonsson Olafur Gisli, MacGregor Stuart, Mateos Marion K, Mayoh Chelsea, Mikkel Sirje, Myrberg Ida Hed, Niinimäki Riitta, Schmiegelow Kjeld, Taskinen Mervi, Vaitkeviciene Goda, Warnqvist Anna, Wolthers Benjamin, Harila-Saari Arja, Ranta Susanna

Abstract excerpt

Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1,464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. Genome-wide association studies, and a candidate single-nucleotide polymorphism (SNP; n=19) study were...

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PMID: 35354251
DOI: 10.3324/haematol.2021.280016
PMCID: PMC9521239

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