Article
Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia.
Oncotarget - 6 Jun 2017
Liu Shu-Guang, Gao Chao, Zhang Rui-Dong, Zhao Xiao-Xi, Cui Lei, Li Wei-Jing, Chen Zhen-Ping, Yue Zhi-Xia, Zhang Yuan-Yuan, Wu Min-Yuan, Wang Jian-Xiang, Li Zhi-Gang, Zheng Hu-Yong
Abstract excerpt
High-dose methotrexate (HDMTX) plays an important role in the treatment of acute lymphoblastic leukemia (ALL) although there is great inter-patient variability in the efficacy and toxicity of MTX. The relationship between polymorphisms in genes encoding MTX transporters and MTX response is controversial. In the present study, 322 Chinese children with standard- and intermediate-risk ALL were genotyped for 12...
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