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Article

Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.

Blood - 27 Jun 2013

Radtke Susanne, Zolk Oliver, Renner Bertold, Paulides Marios, Zimmermann Martin, Möricke Anja, Stanulla Martin, Schrappe Martin, Langer Thorsten

Abstract excerpt

The pharmacogenetics of methotrexate (MTX) was investigated in a large cohort of pediatric patients with acute lymphoblastic leukemia (ALL). Four hundred ninety-nine children with ALL from the ALL-BFM (Berlin-Frankfurt-Münster) 2000 trial who received 1996 courses of MTX at 5 g/m(2) were genotyped for 8 single nucleotide polymorphisms in 5 candidate genes of the MTX/folate pathway. Patients' MTX pharmacokinetics,...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multidrug Resistance-Associated Protein 2

Share to Neoplasm, Residual

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Source

Identifiers

PMID: 23652803
DOI: 10.1182/blood-2013-01-480335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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