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Article

Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment.

Genes - 24 Apr 2020

Kotur Nikola, Lazic Jelena, Ristivojevic Bojan, Stankovic Biljana, Gasic Vladimir, Dokmanovic Lidija, Krstovski Nada, Milosevic Goran, Janic Dragana, Zukic Branka, Pavlovic Sonja

Abstract excerpt

Methotrexate (MTX) is one of the staples of pediatric acute lymphoblastic leukemia (ALL) treatment. MTX targets the folate metabolic pathway (FMP). Abnormal function of the enzymes in FMP, due to genetic aberrations, leads to adverse drug reactions. The aim of this study was to investigate variants in pharmacogenes involved in FMP and their association with MTX pharmacokinetics (MTX elimination profile) and...

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Identifiers

PMID: 32344632
DOI: 10.3390/genes11040468
PMCID: PMC7230684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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