Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

doi:10.1200/JCO.2013.53.0808

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Article

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2014

Bhojwani Deepa, Sabin Noah D, Pei Deqing, Yang Jun J, Khan Raja B, Panetta John C, Krull Kevin R, Inaba Hiroto, Rubnitz Jeffrey E, Metzger Monika L, Howard Scott C, Ribeiro Raul C, Cheng Cheng, Reddick Wilburn E, Jeha Sima, Sandlund John T, Evans William E, Pui Ching-Hon, Relling Mary V

Abstract excerpt

PURPOSE: Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on safety of intrathecal and high-dose MTX rechallenge in patients with neurotoxicity. PATIENTS AND METHODS: Prospective...

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PMID: 24550419
DOI: 10.1200/JCO.2013.53.0808
PMCID: PMC3948096

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