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Article

Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.

American journal of hematology - 1 Jan 2011

Vagace Jose Manuel, Caceres-Marzal Cristina, Jimenez Mercedes, Casado Maria Soledad, de Murillo Silvia Gonzalez, Gervasini Guillermo

Abstract excerpt

Subacute methotrexate neurotoxicity (MTX-NT) may occur days to weeks after systemic or intrathecal (IT) MTX administration and is often manifest by stroke-like symptoms. The pathogenesis of MTX-NT has mainly been associated with cerebral folate homeostasis, but the specific mechanism leading to t...

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Source

Identifiers

PMID: 21064136
DOI: 10.1002/ajh.21897

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21064136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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