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MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

1 Mar 2017

Abstract excerpt

Abstract: Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this...

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PMID: 28392709
DOI: 10.2147/pgpm.s107047

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MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapyPMID 28392709Read ↗

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