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Article

Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2015

Chen Yang, Shen Zuojun

Abstract excerpt

The antifolate drug methotrexate (MTX) is widely used in the treatment of various neoplastic diseases, including acute lymphoblastic leukemia (ALL). MTX significantly increases cure rates and improves patients' prognosis. Despite that it achieved remarkable clinical success, a large number of patients still suffer from treatment toxicities or side effects. Even to this date, chemotherapeutic regiments have not...

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Source

Identifiers

PMID: 26022160
DOI: 10.1007/s13277-015-3602-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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