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Article

Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia.

European journal of pediatrics - 1 Feb 2024

Zhou Yao, He Haoping, Ding Luping, Wang Tianjiao, Liu Xiaomeng, Zhang Minghao, Zhang Aijun, Fu Jinqiu

Abstract excerpt

This study aims to assess the role of methotrexate-related gene polymorphisms in children with acute lymphoblastic leukemia (ALL) during high-dose methotrexate (HD-MTX) therapy and to explore their effects on serum metabolites before and after HD-MTX treatment. The MTHFR 677C>T, MTHFR 1298A>C, ABCB1 3435C>T, and GSTP1 313A>G genotypes of 189 children with ALL who received chemotherapy with the CCCG-ALL-2020...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37851084
DOI: 10.1007/s00431-023-05267-8

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