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Exploration of individual beta cell function over time <i>in vivo:</i> effects of hyperglycemia and glucagon-like peptide-1 receptor (GLP1R) agonism

2025-04-05

Abstract excerpt

The coordinated function of beta cells within the pancreatic islet is required for the normal regulation of insulin secretion and is partly controlled by specialized “leader” and highly connected “hub” beta-cell subpopulations. Whether cells within these subpopulations are functionally stable in vivo remains unclear. Here, we establish an approach to monitor Ca 2+ dynamics within individual beta cells over time,...

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Literature Corpus work
1636a095-570c-5bea-8c5a-ea75edd3ad8a
DOI
10.1101/2025.03.31.646461
Open publication

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Exploration of individual beta cell function over time <i>in vivo:</i> effects of hyperglycemia and glucagon-like peptide-1 receptor (GLP1R) agonismDOI 10.1101/2025.03.31.646461
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