Novel regulators of islet function identified from genetic variation in mouse islet Ca ²⁺ oscillations

Abstract excerpt

<h4>ABSTRACT</h4> Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca 2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca 2+ dynamics in eight genetically diverse mouse strains. We found high strain variation in response to four conditions: 1) 8 mM glucose; 2) 8 mM glucose...

Topics

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• Amino Acids
• Genetic Variation
• Genome-Wide Association Study
• Glucose
• Insulin
• Islets of Langerhans
• Mice
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

a0903d25-6c52-59fb-849d-bea80af065ef

DOI

10.1101/2022.11.26.517741