A Cell Metamodel Uncovers Mechanistic Drivers of Disease Phenotypes Across Molecular, Cellular, and Tissue Scales

Abstract excerpt

<title>Abstract</title> <p> Understanding how molecular and cellular dynamics regulate tissue function remains a central challenge in biology. Here, we develop a graph-based metamodeling framework for modeling of complex biological systems and apply it to construct a comprehensive metamodel of the β-cell. The metamodel integrates 115 input models that describe various aspects of β-cell physiology across molecula...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Cell Cycle
• Cell Division
• G2 Phase
• Gene Expression Regulation
• Gene Regulatory Networks
• Kinetics
• Models, Genetic

Identifiers and source

Literature Corpus work

cb51c01b-99ab-57b9-a4cf-277bdad16136

DOI

10.21203/rs.3.rs-7731109/v1