Article

Dynamic <i>Ins2</i> gene activity defines β-cell maturity states

2019-07-14

Abstract excerpt

Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We investigated the temporal kinetics of endogenous insulin gene activity using live cell imaging, with complementary experiments employing FACS and single cell RNA sequencing, in β-cel...

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Literature Corpus work: d50674e4-fe96-57d9-8388-3797b9b593b4
DOI: 10.1101/702589

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