The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease

Abstract excerpt

Polycystic kidney disease (PKD) is an important cause of end stage renal disease, but treatment options are limited. While later stages of the disease have been extensively studied, mechanisms driving the initial conversion of renal tubules into cysts are not understood. To identify factors that promote the initiation of cysts we deleted polycystin-2 ( Pkd2 ) in mice and surveyed transcriptional changes before and...

Topics

Open a Topic to create a Post that cites this publication.

• Catalytic Domain
• CDC2 Protein Kinase
• DNA Replication
• Exome Sequencing
• Polycystic Kidney, Autosomal Dominant
• Pyruvate Dehydrogenase Acetyl-Transferring Kinase
• RNA-Seq
• TRPP Cation Channels

Identifiers and source

Literature Corpus work

89a419e1-93ee-539b-9b44-d269c5b5f48f

DOI

10.1101/2023.12.04.23299387