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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease

27 Oct 2022

Abstract excerpt

Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24+ epithelial subpopulation. Long-term-cultured CD24+ cell-derived tubuloids represent a functional human kidney tubule. We show that kidney tubuloids can be used to model the most common inherited kidney...

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PMID: 36303074
DOI: 10.1038/s41588-022-01202-z

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