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Article

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.

Nature medicine - 1 Dec 2007

Piontek Klaus, Menezes Luis F, Garcia-Gonzalez Miguel A, Huso David L, Germino Gregory G

Abstract excerpt

Autosomal dominant polycystic kidney disease is an important cause of end-stage renal disease, for which there is no proven therapy. Mutations in PKD1 (the gene encoding polycystin-1) are the principal cause of this disease. The disease begins in utero and is slowly progressive, but it is not kno...

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Share to Gene Expression Regulation, Developmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17965720
DOI: 10.1038/nm1675
PMCID: PMC2302790

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17965720-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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