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Article

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.

Nature medicine - 1 Dec 2007

Piontek Klaus, Menezes Luis F, Garcia-Gonzalez Miguel A, Huso David L, Germino Gregory G

Abstract excerpt

Autosomal dominant polycystic kidney disease is an important cause of end-stage renal disease, for which there is no proven therapy. Mutations in PKD1 (the gene encoding polycystin-1) are the principal cause of this disease. The disease begins in utero and is slowly progressive, but it is not known whether cystogenesis is an ongoing process during adult life. We now show that inactivation of Pkd1 in mice before...

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Source

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Identifiers

PMID: 17965720
DOI: 10.1038/nm1675
PMCID: PMC2302790

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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