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Article

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.

BMC nephrology - 2 Sept 2010

Koupepidou Panayiota, Felekkis Kyriacos N, Kränzlin Bettina, Sticht Carsten, Gretz Norbert, Deltas Constantinos

Abstract excerpt

BACKGROUND: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been made in understanding the pathologic mechanism of the disease, the precise orchestration of the early events leading to cyst formation is still unclear. Abnormal cellular proliferation was...

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Source

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Identifiers

PMID: 20813037
DOI: 10.1186/1471-2369-11-23
PMCID: PMC2936873

Genes

PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.PMID 20813037Read ↗

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