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Article

Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia.

Scientific reports - 23 Jul 2021

Friedrich Sebastian, Müller Hannah, Riesterer Caroline, Schüller Hannah, Friedrich Katja, Wörner Carlotta Leonie, Busch Tilman, Viau Amandine, Kuehn E Wolfgang, Köttgen Michael, Hofherr Alexis

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 12 million people worldwide. Mutations in PKD1 and PKD2 cause cyst formation through unknown mechanisms. To unravel the pathogenic mechanisms in ADPKD, multiple studies have investigated transcriptional mis-regulation in cystic kidneys from patients and mouse models, and numerous dysregulated genes and pathways have been described. Yet, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34301992
DOI: 10.1038/s41598-021-94442-8
PMCID: PMC8302622

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