Article

GRK2 deficiency in vascular smooth muscle cellsexacerbates angiotensin II-induced aortic aneurysm formation by increasing vascular inflammation and TGFβRII degradation

2023-07-17

Abstract excerpt

Aortic aneurysm is a life-threatening complication of hypertension-induced cardiovascular dysfunction. Accumulating evidence has proven that G protein-coupled receptor kinase 2 (GRK2) is an important regulator of vascular remodelling and blood pressure. Genetic testing has shown that the expression of transforming growth factor-β type II receptor (TGFβRII) differs significantly between normal and aneurysm tissues....

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Literature Corpus work: 897aa254-8f73-5f04-8200-afb007b66889
DOI: 10.21203/rs.3.rs-3077564/v1

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