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Article

ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.

Circulation research - 18 Aug 2017

Liu Renjing, Lo Lisa, Lay Angelina J, Zhao Yang, Ting Ka Ka, Robertson Elizabeth N, Sherrah Andrew G, Jarrah Sorour, Li Haibo, Zhou Zhaoxiong, Hambly Brett D, Richmond David R, Jeremy Richmond W, Bannon Paul G, Vadas Mathew A, Gamble Jennifer R

Abstract excerpt

RATIONALE: Thoracic aortic aneurysm (TAA) is a potentially lethal condition, which can affect individuals of all ages. TAA may be complicated by the sudden onset of life-threatening dissection or rupture. The underlying mechanisms leading to TAA formation, particularly in the nonsyndromal idiopathic group of patients, are not well understood. Thus, identification of new genes and targets that are involved in TAA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28701309
DOI: 10.1161/CIRCRESAHA.117.310692

Genes

ARHGAP18
MMP2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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