Article
Protease activated receptor 2 deficiency retards progression of abdominal aortic aneurysms by modulating phenotypic transformation of vascular smooth muscle cells via ERK signaling.
Experimental cell research - 1 Nov 2024
Wang Min, Tang Zhengde, Zeng Huasu, Zhang Alian, Huang Shuying, Ke Jiahan, Gao Lin, Zhang Tiantian, Wang Yue, Chang Alex Chia Yu, Zhang Junfeng, Chen Qizhi, Gu Jun, Wang Changqian
Abstract excerpt
Abdominal aortic aneurysm (AAA) is characterized by localized structural deterioration of the aortic wall, leading to progressive dilatation and rupture. Protease activated receptor 2 (PAR2) dependent signaling has been implicated in the pathophysiology of atherosclerosis through the regulation of smooth muscle cell function. However, its role in AAA remains unclear. This study investigates the function and...
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