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Article

GDF11 Regulates Vascular Smooth Muscle Cell Phenotype Switching to Prevent Aortic Aneurysm Formation.

Cardiovascular drugs and therapy - 1 Jun 2026

Su Xiang, Chen Lulu, Qiu Yihui, Yang Yajing, Chen Bicheng

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a chronic aortic disease that currently lacks effective pharmacological treatments. Growth Differentiation Factor 11 (GDF11) is a member of transforming growth factor β (TGF-β) superfamily associated with cardiovascular diseases. Transcriptomic analysis of GSE57691 revealed significantly reduced GDF11 expression in AAA tissues, with further decline from early- to advanced-stage...

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Share to Angiotensin II
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Proteins

Share to Mice, Knockout, ApoE

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 41240221
DOI: 10.1007/s10557-025-07814-x

Genes

GDF11
ACTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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