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Article

Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.

Circulation research - 5 Feb 2016

Zhang Peng, Hou Siyuan, Chen Jicheng, Zhang Jishuai, Lin Fuyu, Ju Renjie, Cheng Xuan, Ma Xiaowei, Song Yao, Zhang Youyi, Zhu Minsheng, Du Jie, Lan Yu, Yang Xiao

Abstract excerpt

RATIONALE: Aortic aneurysm is a life-threatening cardiovascular disorder caused by the predisposition for dissection and rupture. Genetic studies have proved the involvement of the transforming growth factor-β (TGF-β) pathway in aortic aneurysm. Smad4 is the central mediator of the canonical TGF-β signaling pathway. However, the exact role of Smad4 in smooth muscle cells (SMCs) leading to the pathogenesis of...

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PMID: 26699655
DOI: 10.1161/CIRCRESAHA.115.308040

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